Methionine Transfer Ribonucleic Acids of Avian Myeloblastosis Virus
AUTOR(ES)
Elder, Kay T.
RESUMO
Chick-embryo cells contain four isoaccepting species of methionine transfer RNA (I-IV). One species (I) is the initiator, tRNAfMet, and the others (II, III, and IV) are the donors of internal methionyl residues (tRNAmMet). Over 85% of the tRNAMet in purified avian myeloblastosis virus consists of one tRNAmMet species, which resembles host-cell tRNAMet IV with respect to chromatographic properties on RPC-5, electrophoretic mobility of the terminal methionyl-oligonucleotide, and activity in cell-free protein synthesis in response to synthetic and natural messenger RNAs. Thus, tRNAMet IV of avian myeloblastosis virus is structurally indistinguishable from the corresponding host-cell species, and, although not involved in initiation of viral protein synthesis, is able to function in peptide-chain elongation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=427117Documentos Relacionados
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