Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata.
AUTOR(ES)
Otten, S
RESUMO
Microbial transformation of lapachol, a naturally occurring naphthoquinone, was carried out by Curvularia lunata (NRRL 2178). The fungus brings about oxidative cyclization of the substrate to dehydro-alpha-lapachone, which was isolated and characterized by nuclear magnetic resonance and mass spectral analyses; its structure was verified by chemical synthesis. The metabolite is a naturally occurring chromene possessing antibacterial and antitumor activities.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=243482Documentos Relacionados
- Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.
- Microbial Transformations of Natural Antitumor Agents: O-Demethylation of Vindoline by Sepedonium chrysospermum
- Microbial transformations of natural antitumor agents: use of solubilizing agents to improve yields of hydroxylated ellipticines.
- Microbial Transformations of Natural Antitumor Agents: Products of Rotenone and Dihydrorotenone Transformation by Cunninghamella blakesleeana
- Microbial Transformations of Natural Antitumor Agents: Products of Rotenone and Dihydrorotenone Transformation by Cunninghamella blakesleeana
