Microbial Transformations of Natural Antitumor Agents: Products of Rotenone and Dihydrorotenone Transformation by Cunninghamella blakesleeana
AUTOR(ES)
Sariaslani, F. Sima
RESUMO
Various species of Absidia, Aspergillus, Cunninghamella, Trichothecium, Penicillium, and Phanerochaete were found to transform rotenone to one or more metabolites. Two biotransformation products were isolated from a preparative-scale incubation of rotenone with Cunninghamella blakesleeana and identified as 1′,2′-dihydro-1′,2′-dihydroxyrotenone and 3′-hydroxyrotenone (amorphigenin). The catalytic reduction of the isopropylene side chain of rotenone resulted in the formation of 1′,2′-dihydrorotenone. The latter was transformed by C. blakesleeana to 2′-hydroxy-1′,2′-dihydrorotenone.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=242333Documentos Relacionados
- Microbial Transformations of Natural Antitumor Agents: Products of Rotenone and Dihydrorotenone Transformation by Cunninghamella blakesleeana
- Microbial transformations of natural antitumor agents: oxidation of lapachol by Penicillium notatum.
- Microbial Transformations of Natural Antitumor Agents: O-Demethylation of Vindoline by Sepedonium chrysospermum
- Microbial transformations of natural antitumor agents: conversion of lapachol to dehydro-alpha-lapachone by Curvularia lunata.
- Microbial transformations of natural antitumor agents: use of solubilizing agents to improve yields of hydroxylated ellipticines.
