Mitogenic activity in human embryonic fibroblasts early after infection by human cytomegalovirus.

AUTOR(ES)

Takehara, N

RESUMO

We have characterized the nonspecific lymphocyte stimulation by extracts of human cytomegalovirus-infected human embryonic fibroblasts. Cell extracts prepared at 5 h postinfection (early extract) and 72 h postinfection (late extract) were both highly mitogenic in lymphocyte preparations from adult blood, cord blood, and rabbit blood. Maximum stimulation of the lymphocytes was observed on day 3 after the addition of early or late extract under optimal conditions. Early extract stimulated both the E-rosetting and the EAC-rosetting subpopulations of human lymphocytes. The mitogenic activity appeared before 5 h postinfection and was fairly stable at 30 degrees C for 5 h.

Documentos Relacionados

• Susceptibility of lymphoblastoid cells to infection with human cytomegalovirus.
• Interstitial pneumonia and subclinical infection after intranasal inoculation of murine cytomegalovirus.
• Blastogenic response of human lymphocytes to early antigen(s) of human cytomegalovirus.
• Modulation of RANTES production by human cytomegalovirus infection of fibroblasts.
• Simultaneous pulmonary infection with respiratory syncytial virus and human cytomegalovirus.