Modelling extreme stretching of DNA.
AUTOR(ES)
Lebrun, A
RESUMO
Molecular modelling with Jumna is used to study extreme stretching of the DNA double helix. The results, which correlate well with recent nanomanipulation experiments, show how the double helix can be extended to twice its normal length before its base pairs break. Depending on the way the duplex is stretched two types of conformation can occur, either an unwound flat ribbon or a narrow fibre with negatively inclined base pairs. The energetics of both types of deformation are similar and existing structures show that at least the flat ribbon form can exist locally under biological conditions.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145932Documentos Relacionados
- Modelling of the binding specificity in the interactions of cationic porphyrins with DNA.
- Molecular modelling of the interactions of tetra-(4-N-methylpyridyl) porphin with TA and CG sites on DNA.
- Stretching DNA with optical tweezers.
- DNA stretching on functionalized gold surfaces.
- Rat hepatoma cells nucleolar DNA. 2. Analysis of nucleolar DNA.