Modelo experimental de doença pulmonar intersticial fibrosante associado à terapia celular utilizando células mononucleares de medula óssea / Fibrotic interstitial pulmonary disease: experimental model and bone marrow mononuclear cell therapy
AUTOR(ES)
Rosa Maria Cabral
DATA DE PUBLICAÇÃO
2007
RESUMO
Fibrotic Interstitial pulmonary illnesses affect men, women and children, and presents bad prognostic, 3-5 years depending on the diagnostic confirmation, mainly in idiopathic pulmonary fibrosis. Recent studies demonstrate the capacity of the stem cells in differentiating into different cellular lineages and different tissues, as in heart, liver, gastrointestinal, nervous system and lung. The objectives of this study were to investigate the possibility to consider the swine as experimental model of fibrotic pulmonary disease and experimental stem cell therapy. Bleomycin sulphate was injected into the trachea to induce the pulmonary disease in control and treatment groups. High resolution computed scan (TCAR) was carried out in both groups after the confirmation of the disease. The tomographic analyses showed that the interstitial illness was established after three months of the bleomicine infusion. Histologic investigation revealed the viability of the tested model and the imunohistochemical analyses suggest the migration of the mononuclear cells to the lungs, as well as the presence of new cellular populations that would indicate probable reorganization of the pulmonary parenchyma.
ASSUNTO(S)
bleomicina bleomycin bone marrow mononuclear cells doença pulmonar intersticial fibrosante células mononucleares de medula Óssea fibrotic interstitial pulmonary disease
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