Modulation of a surface antigen of Entamoeba histolytica in response to bacteria.
AUTOR(ES)
Bhattacharya, A
RESUMO
Changes in the cell surface of Entamoeba histolytica, a human intestinal parasite and the causative agent of amebic dysentery, were examined with a monoclonal antibody, 2D7.10, which selectively recognizes carbohydrate epitopes in some axenic amebic strains. While high-level expression of this epitope was observed in axenic amebae, it was either absent or present only in small amounts in xenic amebae. Furthermore, reassociation of the axenic amebae with intestinal flora resulted in loss of the 2D7.10 epitope. Our data suggest that surface antigens of E. histolytica can be modulated in response to bacteria and may provide an explanation for the observed influence of bacteria on amebic virulence.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=257054Documentos Relacionados
- Biochemical characterization of rat colonic mucins secreted in response to Entamoeba histolytica.
- cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica.
- Suppression of T-lymphocyte responses to Entamoeba histolytica antigen by immune sera.
- Modulation of tumor necrosis factor production by macrophages in Entamoeba histolytica infection.
- Rapid diagnosis of Entamoeba infection by using Entamoeba and Entamoeba histolytica stool antigen detection kits.
