Molecular and cytogenetic evidence for the location of Tdy and Hya on the mouse Y chromosome short arm.
AUTOR(ES)
Roberts, C
RESUMO
Using a combination of in situ mapping and DNA analysis with recombinant DNA probes specific for the Sxr region of the mouse Y chromosome, we show that both the gene(s) controlling sex determination and the expression of the male-specific antigen H-Y (Tdy and Hya, respectively) are located on the minute short arm of the mouse Y chromosome. We demonstrate that the H-Y- variant of Sxr (Sxr') arose by a partial deletion within the Sxr region. Also, we show that intrachromosomal recombination between the Y short arm and Sxr' can sometimes occur during male meiosis, restoring the deleted DNA sequences and resulting in an H-Y+ mouse (male 719 in this paper). Based on these results, we propose a model for the generation of the original Sxr region and the Sxr' and Sxr719 variants.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=281989Documentos Relacionados
- A DNA fragment from the human X chromosome short arm which detects a partially homologous sequence on the Y chromosomes long arm.
- Translocation of chromosome 4 and 9 with ring formation of chromosome 4 short arm.
- Further evidence localising the gene for Hunter's syndrome to the distal region of the X chromosome long arm.
- Clinical features of nine males with molecularly defined deletions of the Y chromosome long arm.
- Muscular dystrophy in an X; 1 translocation female suggests that Duchenne locus is on X chromosome short arm.