Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

AUTOR(ES)

Camargo, A.A., Nunes, D.N., Samaia, H.B., Liu, L., Collins, V.P., Simpson, A.J.G., Dias-Neto, E.

FONTE

Brazilian Journal of Medical and Biological Research

DATA DE PUBLICAÇÃO

2001-10

RESUMO

DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed.

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