Molecular identification of the insect adipokinetic hormone receptors
AUTOR(ES)
Staubli, Frank
FONTE
The National Academy of Sciences
RESUMO
The insect adipokinetic hormones (AKHs) are a large family of peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion, but that also contribute to hemolymph sugar homeostasis. Here, we have identified the first insect AKH receptors, namely those from the fruitfly Drosophila melanogaster and the silkworm Bombyx mori. These results represent a breakthrough for insect molecular endocrinology, because it will lead to the cloning of all AKH receptors from all model insects used in AKH research, and, therefore, to a better understanding of AKH heterogeneity and actions. Interestingly, the insect AKH receptors are structurally and evolutionarily related to the gonadotropin-releasing hormone receptors from vertebrates.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=122543Documentos Relacionados
- Juvenile hormone receptors in insect larval epidermis: identification by photoaffinity labeling.
- Insect NMDA receptors mediate juvenile hormone biosynthesis
- Molecular Determinants of Differential Ligand Sensitivities of Insect Ecdysteroid Receptors
- Molecular cloning and functional expression of the first two specific insect myosuppressin receptors
- Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors.