Molecular phylogenetic analyses of the mitochondrial ADP-ATP carriers: The Plantae/Fungi/Metazoa trichotomy revisited
AUTOR(ES)
Löytynoja, Ari
FONTE
The National Academy of Sciences
RESUMO
We investigated the basal phylogeny of eukaryotes through analyses of sequences from the ADP–ATP mitochondrial carrier, a transmembrane protein that is stable in function across eukaryote kingdoms. The ADP–ATP data strongly suggest the grouping of Plantae and Fungi to the exclusion of Metazoa. We implemented several procedures to avoid pervasive analytical artifacts such as erroneous alignment, random rooting, long branch attraction, and misidentification of noisy characters. The quest of an eukaryote tree that would be largely consistent across multiple loci might be essentially illusory because of differential lineage sorting, horizontal gene transfer, and the chimeric nature of early eukaryotes. Better understanding of these evolutionary parameters, requiring separate phylogenetic analyses of multiple independent loci, is fundamental for resolution of the modes of emergence and evolution of the major eukaryote lineages.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=56939Documentos Relacionados
- Conserved properties of hydrogenosomal and mitochondrial ADP/ATP carriers: a common origin for both organelles
- Electrical currents associated with nucleotide transport by the reconstituted mitochondrial ADP/ATP carrier.
- High-Chloride Concentrations Abolish the Binding of Adenine Nucleotides in the Mitochondrial ADP/ATP Carrier Family
- Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane.
- Sequence of the bovine mitochondrial phosphate carrier protein: structural relationship to ADP/ATP translocase and the brown fat mitochondria uncoupling protein.