Molecular regulation of receptors: interaction of beta-estradiol and progesterone with the muscarinic system.
AUTOR(ES)
Sokolovsky, M
RESUMO
The effects of various substrates on the binding of agonists to muscarinic receptors were studied in the rat hypothalamus and adenohypophysis by competition experiments using the highly specific tritiated muscarinic antagonist N-methyl-4-piperidyl benzilate. It was found that agonist binding properties were affected only by the steroid sex hormones (beta-estradiol and progesterone), both of which resulted in a decrease in the proportion of high-affinity binding sites and a decrease in the dissociation constant. This suggests a link between the muscarinic system and the mechanism by which these steroids exert their gonadotropin-releasing effect on the adenohypophysis. We propose a model to depict the putative relationship between the muscarinic system and other receptor systems, including that which controls the steroid sex hormones.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348784Documentos Relacionados
- Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine.
- Identification of 17 beta-estradiol as the estrogenic substance in Saccharomyces cerevisiae.
- Direct effects of 17 beta-estradiol on trabecular bone in ovariectomized rats.
- Effect of beta-estradiol on production of the cell-detaching factor of Trichomonas vaginalis.
- 17 beta-estradiol acts directly on the clonal osteoblastic cell line UMR106.