Monitorização biológica na exposição ocupacional ao cobalto, aspectos toxicológicos e analíticos associados a um sistema de qualidade. / Biological monitoring of occupational exposure to cobalt, toxicological and analytical aspects associated with a Quality System

AUTOR(ES)

Atecla Nunciata Lopes Alves

DATA DE PUBLICAÇÃO

1999

RESUMO

This work has the purpose of an analytical review of blood and urines cobalt quantification in order to be used in biological monitoring. A proposal of alternatives and feasible methodologies that habe been found are based upon the crutical study associated with a Quality system. The toxic effects observed in exposure to different cobalt compounds, the dose-effect relationship and dose-response, and the reference values in health and non-exposed population, have brought ACGIH (American Conference of Governmental Industrial Hygienists) of the United States to propose since 1995 a BEI (Biological Exposure Indice) to this kind of exposure. Although Brazil has not included cobalt in the PCMSO (Programa de Controle Médico de Saúde Ocupacional), the use of biological indicator can become a necessity due to toxicological and analytical studies here reviewed and reported in the literature

ASSUNTO(S)

cobalt quality system sistema da qualidade cobalto biological monitoring monitorização biológica

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