Multiple cutaneous melanomas associated with gastric and brain metastases

AUTOR(ES)

Grander, Lara Caroline, Cabral, Fernanda, Lisboa, Alice Paixão, Vale, Gabrielle, Barcaui, Carlos Baptista, Maceira, Juan Manuel Pineiro

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2016-10

RESUMO

Abstract The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases. We also emphasize the importance of clinical examination and dermoscopy of the entire tegument, even after a malignant melanocytic lesion is identified.

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