MUTATION TO NEOSTIGMINE RESISTANCE IN A CHOLINESTERASE-CONTAINING PSEUDOMONAS1

AUTOR(ES)

Searle, Barbara W.

RESUMO

Searle, Barbara W. (Stanford University School of Medicine, Palo Alto, Calif.) and Avram Goldstein. Mutation to neostigmine resistance in a cholinesterase-containing Pseudomonas. J. Bacteriol. 83:789–796. 1962.—In a strain of Pseudomonas fluorescens containing an inducible cholinesterase, the activity of that enzyme is rate-limiting for growth when acetyl-choline is the sole source of carbon or nitrogen. Under these circumstances, neostigmine, a cholinesterase inhibitor, becomes a growth inhibitor.

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