Mutations of Chinese Hamster Somatic Cells from 2-Deoxygalactose Sensitivity to Resistance
AUTOR(ES)
Claverie, Jean-Michel
RESUMO
In Chinese hamster somatic cells, the spontaneous change of phenotype from 2-deoxygalactose sensitivity to resistance was studied using fluctuation test experiments à la Luria and Delbrück (1943) for four Chinese hamster cell strains derived from V79. The results are consistent with true mutational events. The mutation rates are in the range of 1 to 3.5 x 10-5 per cell per generation. The relationship between the 2-deoxygalactose resistance and the galactokinase markers is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213976Documentos Relacionados
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