Mutator and antimutator phenotypes of suppressed amber mutants in genes 32, 41, 44, 45, and 62 in bacteriophage T4.
AUTOR(ES)
Watanabe, S M
RESUMO
Bacteriophage T4 genes 32, 41, 44, 45, 56, and 62 are essential to DNA replication. Amber mutants (suppressed by su+1, su+2, or su+3 bacteria) in these genes were examined for any mutator or antimutator effects on the reversion of a transition mutation. In every case except for mutations in gene 56, elevated or lowered error frequencies were observed. These results indicate the importance of all of the replicative proteins in the determination of error frequency.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=353902Documentos Relacionados
- Persistence of DNA synthesis arrest sites in the presence of T4 DNA polymerase and T4 gene 32, 44, 45 and 62 DNA polymerase accessory proteins.
- Suppressors of gene 32 am mutants that specifically overproduce P32 (unwinding protein) in bacteriophage T4.
- Site Specificity and Variability in the Mutator and Antimutator Effects of Phage T4 Gene 43 Mutants
- Mutator mutations in bacteriophage T4 gene 32 (DNA unwinding protein).
- Semiconservative DNA replication is initiated at a single site in recombination-deficient gene 32 mutants of bacteriophage T4.