Mycobacteriocidal Action of Exogenous Nitric Oxide

AUTOR(ES)

Long, Richard

FONTE

American Society for Microbiology

RESUMO

We tested the hypothesis that exposure of extracellular Mycobacterium tuberculosis to low concentrations (<100 ppm) of nitric oxide (NO) for short periods (24 h or less) will result in microbial killing. We observed that NO had both dose- and time-dependent cidal effects that were very significant by two-way analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively). Conceivably, extracellular bacilli in patients with pulmonary tuberculosis might be vulnerable to exogenous NO.

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