Myosin V processivity: Multiple kinetic pathways for head-to-head coordination

AUTOR(ES)

Baker, Josh E.

FONTE

National Academy of Sciences

RESUMO

Myosin V, a double-headed molecular motor, transports organelles within cells by walking processively along actin, a process that requires coordination between the heads. To understand the mechanism underlying this coordination, processive runs of single myosin V molecules were perturbed by varying nucleotide content. Contrary to current views, our results show that the two heads of a myosin V molecule communicate, not through any one mechanism but through an elaborate system of cooperative mechanisms involving multiple kinetic pathways. These mechanisms introduce redundancy and safeguards that ensure robust processivity under differing physiologic demands.

Documentos Relacionados

• Structure and electronic properties of alkylthiophenes coupled by Head-to-Tail and Head-to-Head regioselectivity
• Head-to-Head Evaluation of Five Chlamydia Tests Relative to a Quality-Assured Culture Standard
• The Gramicidin A Transmembrane Channel: Characteristics of Head-to-Head Dimerized π(L,D) Helices
• In Vitro Amphotericin B Resistance in Clinical Isolates of Aspergillus terreus, with a Head-to-Head Comparison to Voriconazole
• 2,5-Dialkylresorcinol Biosynthesis in Pseudomonas aurantiaca: Novel Head-to-Head Condensation of Two Fatty Acid-Derived Precursors