N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

AUTOR(ES)

van 't Veer, L J

RESUMO

In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.

Documentos Relacionados

• Activation of N-ras in a human melanoma cell line.
• Concomitant K- and N-ras gene point mutations in clonal murine lymphoma.
• Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization.
• All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair. Adult skin from sun-protected and sun-exposed sites responds in an identical manner to RA while neonatal foreskin responds differently.
• BsmI polymorphism in N-ras intron I (RASN)