Natural Diversity in the N Terminus of the Mature Vacuolating Cytotoxin of Helicobacter pylori Determines Cytotoxin Activity
AUTOR(ES)
Letley, D. P.
FONTE
American Society for Microbiology
RESUMO
Naturally occurring noncytotoxic vacA type s2 strains of Helicobacter pylori have a 12-residue extension to the vacuolating cytotoxin (VacA) compared with cytotoxic type s1 strains. We show that adding the region encoding this extension to type s1 vacA completely abolishes vacuolating cytotoxin activity but has no effect on VacA production.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=94518Documentos Relacionados
- Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori.
- Evolution of the Helicobacter pylori Vacuolating Cytotoxin in a Human Stomach
- Binding of the Helicobacter pylori Vacuolating Cytotoxin to Target Cells
- The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity
- Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori.