Natural killer cells and autoimmunity

AUTOR(ES)

French, Anthony R

FONTE

BioMed Central

RESUMO

Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the innate immune system, and in particular natural killer (NK) cells, in stimulating or suppressing autoimmunity. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in modulating T and B cell-mediated autoimmunity.

Documentos Relacionados

• Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity
• Natural killer activating receptors trigger interferon γ secretion from T cells and natural killer cells
• Human and murine inhibitory natural killer cell receptors transfer from natural killer cells to target cells
• Natural killer cells, miscarriage, and infertility
• Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases