Nature of "memory" in T-cell-mediated antibacterial immunity: anamnestic production of mediator T cells.

AUTOR(ES)

North, R J

RESUMO

Mice that survived an immunizing infection with Listeria monocytogenes remained specifically resistant to lethal secondary infection for several months. This acquired, long-lived state of resistance was not dependent on activated macrophages that remained after the primary response. It depended, instead, on an acquired long-lived capacity on the part of immunized mice for generating mediator T cells faster and in larger numbers than normal mice. The number of mediator T cells generated in response to secondary infection was proportional to the level of infection. The results suggest that the accelerated production of mediator T cells that occurs in response to secondary infection represents the expression of a state of immunological T-cell memory.

Documentos Relacionados

• Nature of "memory" in T-cell mediated antibacterial immunity: cellular parameters that distinguish between the active immune response and a state of "memory".
• Inflammatory Lymphocyte in Cell-Mediated Antibacterial Immunity: Factors Governing the Accumulation of Mediator T Cells in Peritoneal Exudates
• T-cell-mediated immunity in persistent Mycobacterium intracellulare infections in mice.
• Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity
• T-cell-mediated control of autoimmunity