Nerve growth factor deprivation results in the reactivation of latent herpes simplex virus in vitro.
AUTOR(ES)
Wilcox, C L
RESUMO
Primary sympathetic neuronal cultures were maintained for up to 5 weeks after inoculation with herpes simplex virus (HSV) without evidence of viral infection. Upon deprivation of nerve growth factor, the cultures produced infectious HSV, indicating that the cultures harbored latent HSV. This study demonstrates a function of nerve growth factor in the maintenance of HSV latency.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283698Documentos Relacionados
- Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro.
- Encephalitis resulting from reactivation of latent herpes simplex virus in mice.
- Reactivation of latent Herpes simplex virus after pneumococcal pneumonia in mice.
- In Vitro System for Studying the Efficacy of Antiviral Agents in Preventing the Reactivation of Latent Herpes Simplex Virus
- Social stress and the reactivation of latent herpes simplex virus type 1
