Netilmicin and Gentamicin: Comparative Pharmacology in Humans
AUTOR(ES)
Riff, Louise J.
RESUMO
Thirteen male subjects received 1 mg of either gentamicin or netilmicin per kg, first intramuscularly and then intravenously. After the intramuscular dose, concentrations of gentamicin in the serum were more variable than those of netilmicin. After the intravenous dose, the distribution phase of netilmicin was twice as rapid as gentamicin. The average half-times of the elimination phase were similar, but there was marked variability among the subjects receiving gentamicin. Serum clearance of netilmicin was more rapid than that of gentamicin and could not be attributed to renal elimination. The data indicate that, after intramuscular administration, netilmicin may produce more predictable blood levels than gentamicin and suggest that the body distribution of netilmicin may differ from that of gentamicin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352037Documentos Relacionados
- Comparison of netilmicin and gentamicin pharmacokinetics in humans.
- Comparative Nephrotoxicities of Netilmicin and Gentamicin in Rats
- Renal disposition of gentamicin, dibekacin, tobramycin, netilmicin, and amikacin in humans.
- Pharmacology of Gentamicin in the Biliary Tract of Humans
- Comparative Clinical Pharmacology of Gentamicin, Sisomicin, and Tobramycin