Neural tube malformations: complex segregation analysis and calculation of recurrence risks.
AUTOR(ES)
Lalouel, J M
RESUMO
Familial data on neural tube malformations in Great Britain were submitted to segregation analysis under the mixed model. Maternal and fetal factors cannot be discriminated in the absence of substantial bodies of data on spina bifida survivors who reproduce or on half-sibs. Early abortion studies would allow differential mortality in utero to be taken into account. After fitting the mixed and generalised single locus models, it is concluded that the multifactorial model can provisionally be used for calculation of recurrence risks. Pathogenic hypotheses implicating twinning seem to rest on little evidence.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1012772Documentos Relacionados
- Recurrence risks for neural tube defects in a genetic counseling clinic population.
- Recurrence risk of neural tube defects.
- Neural tube malformations and trace elements in water.
- Season and interval for recurrence of neural tube defects.
- Recurrence rates for neural tube defects and vitamin supplementation