Neuronal Dynamics and Axonal Flow, V. The Semisolid State of the Moving Axonal Column
AUTOR(ES)
Weiss, Paul A.
RESUMO
Evidence assembled since the first comprehensive description of “axonal flow”, by deformation analysis, electron microscopy, cinemicrography, and microrheology, has confirmed that the axon of the mature neuron is (a) a semisolid column; (b) in cellulifugal motion at about 1 μm/min (1 mm per day); (c) continuously reproduced at its perikaryal base; (d) propelled by a microperistaltic pulse wave in its surface; and (e) undergoing internal dissolution at the nerve ending. The axon thus “flows” as a structural entity (“axonal flow”), in contradistinction to fast “intraaxonal transport” of molecules and molecular assemblies along internal routes and by mechanisms that are still unknown.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=426520Documentos Relacionados
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