Neutralization of bacteria- and endotoxin-induced hypotension by lipoprotein-free human serum.
AUTOR(ES)
Abdelnoor, A M
RESUMO
Normal human serum and a fraction rich in lipoprotein, Cohn fraction IV1, have been shown in previous studies to detoxify native endotoxin by decreasing lethality for mice, fever in rabbits, and by the alteration of the characteristic endotoxin-anti-endotoxin precipitin pattern in gels. These studies are extended herein and document the ability of normal human serum and fraction IV1 to neutralize the induction of hypotension in rabbits by viable gram-negative bacilli. Further fractionation of serum, using an ultracentrifugal flotation method for producing lipoprotein-free human serum and purified high-density lipoproteins, revealed the lipoprotein-free fraction to be capable of inhibiting endotoxin hypotensive activity and to alter diffusion of endotoxin in gels. On the other hand, the purified high-density lipoproteins failed to negate either activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=347711Documentos Relacionados
- Immunization against bacteria- and endotoxin-induced hypotension.
- Immunization Against Bacteria- and Endotoxin-Induced Hypotension
- Regulation of endotoxin-induced inhibition of macrophage migration by fresh serum.
- Arrest of endotoxin-induced hypotension by transforming growth factor beta1.
- Inhibition of endotoxin-induced activation of human monocytes by human lipoproteins.