Neutralization of Endotoxin Toxicity in Chick Embryos by Antibiotics1
AUTOR(ES)
Rifkind, David
RESUMO
Rifkind, David (University of Colorado Medical Center, Denver), and John D. Palmer. Neutralization of endotoxin toxicity in chick embryos by antibiotics. J. Bacteriol. 92:815–819. 1966.—Three cationic cyclic polypeptide antibiotics, polymyxin B sulfate colistin sulfate, and tyrocidine hydrochloride, were shown to neutralize endotoxin lethality in chick embryos. The neutralizing potency of these antibiotics was approximately equivalent, 0.06 to 0.11 μmole of antibiotic per μg of endotoxin. Methane sulfonation of colistin resulted in a 13-fold decrease in endotoxin-neutralizing potency. Other cationic cyclic polypeptide antibiotics were inactive, as well all other classes of antibiotics tested, including the neutral cyclic polypeptides. Several nonantibiotic polycationic proteins and polymers tested were also inactive. It is suggested that certain cationic cyclic polypeptide antibiotics neutralize by combining directly with the toxic moiety of the endotoxin molecule. Possibly this combination involves the cationic groups of the antibiotics and the polyphosphate groups of the phospholipid component of endotoxin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=276339Documentos Relacionados
- MECHANISM OF PROTECTION BY STEROLS AGAINST POLYENE ANTIBIOTICS1
- REVERSAL BY COMPLEX NATURAL MATERIALS OF GROWTH INHIBITION CAUSED BY ANTIBIOTICS1
- Comparative Sensitivity of Venezuelan Equine Encephalomyelitis Virus Neutralization Tests in Chick Embryos and in Mice 1
- PROBLEMS IN THE SEARCH FOR MICROORGANISMS PRODUCING ANTIBIOTICS1
- SYMPOSIUM ON THE MODE OF ACTION OF ANTIBIOTICS1