New Antiproliferative Polyunsaturated Epoxy-Heneicosane Derivatives Isolated from the Brown Alga Lobophora variegata
AUTOR(ES)
Ávila, Fábio N.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2019-02
RESUMO
Two new polyunsaturated 3,4-epoxy-heneicosane derivatives named as epoxy-lobophorene A and epoxy-lobophorene B were isolated from the brown alga Lobophora variegata, in addition to nine known compounds. The structures of the new compounds were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The isolated compounds were submitted to antiproliferative assays against the human colon cancer cell line HCT-116, human metastatic prostate cancer PC-3M, murine metastatic melanoma B16-F10 and murine fibroblast cell line L929 and also tested as antibacterial. Both 3,4-epoxy lobophorene A and 3,4-epoxy lobophorene B depicted moderate antiproliferative effect against cell lines. None of them showed antibacterial activity.
Documentos Relacionados
- Efeitos do polissacarídeo sulfatado da alga marinha parda Lobophora variegata (Lamourox) no processo inflamatório agudo.
- Diterpenes from marine brown alga Dictyota guineensis (Dictyotaceae, Phaeophyceae)
- Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants
- Anti-snake venom effect of secodolastane diterpenes isolated from Brazilian marine brown alga Canistrocarpus cervicornis against Lachesis muta venom
- Intraspecific variation of meroditerpenoids in the brown alga Stypopodium zonale guiding the isolation of new compounds