New Approach for the Stereoselective Synthesis of (+)-epi-Cytoxazone
AUTOR(ES)
Miranda, Izabel L.
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2019-03
RESUMO
The stereoselective total synthesis of (+)-epi-cytoxazone was performed satisfactorily in 8 steps, in 17% overall yield, via a novel route from 2,3-O-(3-pentylidene)-(R)-glyceraldehyde. The bulky group alkene-ketal allowed intramolecular control of the target molecule's asymmetric centers in the dihydroxylation step by promoting the approach of OsO4 to the face opposite to that of the ketal group.
Documentos Relacionados
- An approach to the stereoselective synthesis of Sp-dinucleoside phosphorothioates using phosphotriester chemistry.
- Synthetic Studies toward (−)-Cleistenolide: Highly Stereoselective Synthesis of New γ-Lactone Subunits
- A new approach for the synthesis of 3-substituted cytotoxic nor-β-lapachones
- A new approach for the synthesis of bioactive heteroaryl thiazolidine-2,4-diones
- An alternative approach to aminodiols from Baylis-Hillman adducts: stereoselective synthesis of chloramphenicol, fluoramphenicol and thiamphenicol
