NEW EMBO MEMBER’S REVIEW: Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression

AUTOR(ES)

Christofori, Gerhard

FONTE

Oxford University Press

RESUMO

Changes in cell–cell and cell–matrix adhesion accompany the transition from benign tumours to invasive, malignant cancer and the subsequent metastatic dissemination of tumour cells. This review discusses a possible role of cell adhesion molecules not only in redirecting a tumour cell’s adhesive capabilities but also in modulating intracellular signalling, and with it, tumour malignancy.

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