NEW EMBO MEMBER’S REVIEW: For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin–proteasome connection
AUTOR(ES)
Kostova, Zlatka
FONTE
Oxford University Press
RESUMO
The surveillance of the structural fidelity of the proteome is of utmost importance to all cells. The endoplasmic reticulum (ER) is the organelle responsible for proper folding and delivery of proteins to the secretory pathway. It contains a sophisticated protein proofreading and elimination mechanism. Failure of this machinery leads to disease and, finally, to cell death. Elimination of misfolded proteins requires retrograde transport across the ER membrane and depends on the central cytoplasmic proteolytic machinery involved in cellular regulation: the ubiquitin–proteasome system. The basics of this process as well as recent advances in the field are reviewed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=155985Documentos Relacionados
- NEW EMBO MEMBER’S REVIEW: NF-κB and virus infection: who controls whom
- NEW EMBO MEMBER’S REVIEW: Diversity of protein–protein interactions
- NEW EMBO MEMBER’S REVIEW: The integrin–actin connection, an eternal love affair
- NEW EMBO MEMBER’S REVIEW: Addressing protein localization within the nucleus
- NEW EMBO MEMBER’S REVIEW: Addressing protein localization within the nucleus