New Plasmid (pTU512), Mediating Resistance to Penicillin, Erythromycin, and Kanamycin, from Clinical Isolates of Staphylococcus aureus
AUTOR(ES)
Kono, Megumi
RESUMO
Multiply drug-resistant strains of Staphylococcus aureus were isolated from pediatric patients with severe staphylococcal infections in 1974 through 1976. Resistance to benzylpenicillin, erythromycin, and kanamycin was jointly eliminated without exception from these multiply drug-resistant strains by treatment with ethidium bromide. It was also found that the triple drug resistance in a representative strain, TK512-200, was always transduced to a susceptible strain simultaneously. Moreover, a single class of plasmid deoxyribonucleic acid was isolated from a transductant and found to be 14.4 ± 0.6 μm in length, with a molecular weight corresponding to 29.8 × 106. From these results, it is concluded that the plasmid (pTU512) is a new one, mediating resistance to penicillin, erythromycin, and kanamycin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=352311Documentos Relacionados
- Broad geographical distribution of homologous erythromycin, kanamycin, and streptomycin resistance determinants among group D streptococci of human and animal origin.
- Isolation and Characterization of a Kanamycin Resistance Plasmid from Staphylococcus aureus
- Transfer of Erythromycin Resistance from Poultry to Human Clinical Strains of Staphylococcus aureus
- Anaerobic Resistance of Clinical Isolates of Staphylococcus aureus to Aminoglycosides†
- PERSISTENCE OF ANTIBIOTICS IN BLOOD OF PATIENTS WITH ACUTE RENAL FAILURE. III. PENICILLIN, STREPTOMYCIN, ERYTHROMYCIN AND KANAMYCIN*†