New rat cell line that is highly susceptible to transformation by several oncogenes.

AUTOR(ES)

Liboi, E

RESUMO

We describe here a new cell line, EL2, which spontaneously arose from primary rat embryo fibroblasts and has the distinctive property of being highly susceptible to a number of different transforming genes. The high susceptibility is expressed not only in high transformation frequencies but, most importantly, in an unusually high rate of growth of EL2 transformants under selective conditions, i.e., in soft agar or as foci. The biological characteristics of EL2 cells greatly accelerate the isolation of transformants from known oncogenes and could be useful to detect new transforming genes.

Documentos Relacionados

• A cell mutant that exhibits temperature-dependent sensitivity to transformation by various oncogenes.
• A human astrocytoma cell line is highly susceptible to infection with Trypanosoma cruzi
• Effect of cellular determination on oncogenic transformation by chemicals and oncogenes.
• Stimulation of pancreatic islet beta-cell replication by oncogenes.
• Insulin-like growth factor I receptor signaling in transformation by src oncogenes.