New TEM Variant (TEM-92) Produced by Proteus mirabilis and Providencia stuartii Isolates

AUTOR(ES)

de Champs, Christophe

FONTE

American Society for Microbiology

RESUMO

The sequences of the blaTEM genes encoding TEM-92 in Proteus mirabilis and Providencia stuartii isolates were determined and were found to be identical. Except for positions 218 (Lys-6) and 512 (Lys-104), the nucleotide sequence of blaTEM-92 was identical to that of blaTEM-20, including the sequence of the promoter region harboring a 135-bp deletion combined with a G-162→T substitution. The deduced amino acid sequence of TEM-92 differed from that of TEM-52 by the presence of a substitution (Gln-6→Lys) in the peptide signal.

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