Nicotine activates immature “silent” connections in the developing hippocampus
AUTOR(ES)
Maggi, Laura
FONTE
The National Academy of Sciences
RESUMO
In the hippocampus at birth, most glutamatergic synapses are immature and functionally “silent” either because the neurotransmitter is released in insufficient amount to activate low-affinity α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptors or because the appropriate receptor system is missing or nonfunctional. Here we show that, in the newborn rat, a brief application of nicotine at immature Schaffer collateral-CA1 connections strongly enhances neurotransmitter release and converts presynaptically silent synapses into conductive ones. This effect is persistent and can be mimicked by endogenous acetylcholine released from cholinergic fibers. Thus, during a critical period of postnatal development, activation of nicotinic acetylcholine receptors contributes to the maturation of functional synaptic contacts and the wiring of adult hippocampal circuitry.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=149958Documentos Relacionados
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