Nitric oxide synthase activity and endogenous inhibitors in rats recovered from allergic encephalomyelitis
AUTOR(ES)
Teixeira, SA, Varriano, AA, Dias, AA, Martins Porto, R, Muscará, MN
FONTE
Memórias do Instituto Oswaldo Cruz
DATA DE PUBLICAÇÃO
2005-03
RESUMO
We have previously reported that in comparison with normal rats, the presence of experimental allergic encephalomyelitis (EAE) leads to decreased endogenous inhibitory activity (EIA) of Ca2+-dependent nitric oxide synthase (NOS) in both brain and serum, and increased expression of protein 3-nitrotyrosine (NT) in brain. In this work we show that animals recovered from the clinical signs of EAE are not different from controls in terms of either brain NOS activity, EIA of NOS, or NT expression. These results suggest that parallel to the reversal of the disease symptoms, a normalization of the production of nitric oxide and related species occurs.
Documentos Relacionados
- Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice
- Inducible nitric oxide synthase in Theiler's murine encephalomyelitis virus infection.
- Nitric Oxide Production and Mononuclear Cell Nitric Oxide Synthase Activity in Malaria-Tolerant Papuan Adults
- Direct measurement of nitric oxide generation from nitric oxide synthase
- Arginine transport in human liver. Characterization and effects of nitric oxide synthase inhibitors.