Noninfectious rotavirus (strain RRV) induces an immune response in mice which protects against rotavirus challenge.
AUTOR(ES)
Offit, P A
RESUMO
We found that female adult mice parenterally inoculated with noninfectious rotavirus (simian strain RRV) developed virus-specific neutralizing antibodies in the serum; newborn mice from these dams were protected against RRV-induced gastroenteritis. In addition, mice parenterally inoculated with noninfectious RRV developed virus-specific cytotoxic T-lymphocyte precursors in the spleen. Replication of rotavirus in intestinal epithelial cells was apparently not required to induce rotavirus-neutralizing antibodies or rotavirus-specific cytotoxic T lymphocytes. Parenteral immunization of infants and young children with noninfectious rotaviruses may induce an immune response which protects against rotavirus challenge.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=267448Documentos Relacionados
- Semliki Forest virus E2 envelope epitopes induce a nonneutralizing humoral response which protects mice against lethal challenge.
- Immunization with baculovirus-expressed VP4 protein passively protects against simian and murine rotavirus challenge.
- Intranasal immunization induces long-term protection in mice against a Chlamydia trachomatis genital challenge.
- Antibody against the capsule of Vibrio cholerae O139 protects against experimental challenge.
- Oral immunization of rabbits with enterotoxigenic Escherichia coli protects against intraintestinal challenge.