Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.

AUTOR(ES)

Perkins, K K

RESUMO

A homolog of mammalian enhancer binding factor AP-1 was detected in Drosophila and was purified from embryo nuclear extracts by sequence-specific DNA affinity chromatography. The purified fraction, dAP-1, displays the sequence specificity as well as transcriptional activation properties of mammalian AP-1 and consists of two major proteins of mol. wts 40 and 70 kd. Antibody cross-reactivity experiments suggest that these proteins are Drosophila homologs of proto-oncogene products, Jun and Fos. The Drosophila Jun- and Fos-related antigens, when separated, are individually capable of sequence-specific DNA binding, and the Jun-related antigen activates transcription in vitro.

Documentos Relacionados

• SRY protein enhances transcription of Fos-related antigen 1 promoter constructs.
• Transcription factor Fos-related antigen 1 is an effective target for a breast cancer vaccine
• FosB mutant mice: Loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine’s psychomotor and rewarding effects
• The Fos-related antigen Fra-1 is an activator of bone matrix formation
• Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei.