Novel metabolites from Penicillium crustosum, including penitrem E, a tremorgenic mycotoxin.
AUTOR(ES)
Kyriakidis, N
RESUMO
Two new indolic metabolites were isolated from Penicillium crustosum and separated from other penitrem mycotoxins by high-performance liquid chromatography. Penitrem D is a deoxy-penitrem A. Penitrem E is dechloro-penitrem A and was shown to be tremorgenic in mice, although it has only one-third of the activity of penitrem A. Roquefortine was also shown, for the first time, to be an important metabolic product of P. crustosum.
