Nucleoside 5'-phosphordiamidates, synthesis and some properties.

AUTOR(ES)

Simoncsits, A

RESUMO

A simple way of preparing nucleoside 5'-phosphordiamidate is described. The procedure is based on the ammonolysis of nucleoside 5'-phosphordichloridates by dilute aqueous ammonium hydroxide. The behaviour of nucleoside phosphordiamidates under acidic and alkaline conditions is also reported. Alkaline hydrolysis results in the formation of the parent nucleoside, whereas one amide group can be removed selectively by mild acid hydrolysis. This property of nucleoside phosphordiamidates served as a basis for the elaboration of a simple synthesis of nucleoside phosphoramidates starting from nucleosides.

Documentos Relacionados

• Zwitterionic oligodeoxyribonucleotide N3'-->P5' phosphoramidates: synthesis and properties.
• Oligo-2'-fluoro-2'-deoxynucleotide N3'-->P5' phosphoramidates: synthesis and properties.
• Glutamine synthetase of pseudomonads: some biochemical and physicochemical properties.
• Respiratory burst oxidase from human neutrophils: purification and some properties.
• Purification of Tetrahymena actin reveals some unusual properties.