Nucleoside conformations. XVII. A PMR study of 2′-anhydronucleosides and comparison with X-ray data

AUTOR(ES)

Guschlbauer, Wilhelm

RESUMO

A series of 2′-cyclo-nucleosides (2,2′-O-anhydro-uridine, -N3-uridine and cytidine and 8,2′-S-anhydro-guanosine) have been studied by PMR in DMSO and D2O. As expected these compounds are quite rigid, but their solution conformation is considerably different from that observed in single crystal x-ray studies. While the pyrimidine cyclonucleosides in the crystal form show a C4′-endo conformation (pseudorotational phase angle P=212° to 233°), their solution conformation is C1′-exo (P=130° to 138°) and the cyclothioguanosine shows a closely similar one (P=112°). Exocyclic rotamer distribution is different in the various compounds.

Documentos Relacionados

• A comparison of the conformations adopted by some 5-bromovinyl-2'-deoxyuridines and a correlation with their antiviral properties: an X-ray study.
• X-ray structure of nucleoside diphosphate kinase.
• Iron distances in hemoglobin: comparison of x-ray crystallographic and extended x-ray absorption fine structure studies.
• Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data.
• Conformations of A-DNA and B-DNA in agreement with fiber X-ray and infrared dichroism.