Nucleotide sequence of the Salmonella typhimurium mutB gene, the homolog of Escherichia coli mutY.
AUTOR(ES)
Desiraju, V
RESUMO
The mutB gene of Salmonella typhimurium is involved in a methylation-independent repair pathway specific for A/G or A/C mismatches and is the homolog of the Escherichia coli mutY gene. The mutB gene of S. typhimurium was cloned and sequenced. The isolated mutB clone reduced the mutation rate of the mutB mutant to wild-type levels and also restored A/G mismatch-specific nicking activity, which is defective in mutB extracts. The amino acid sequence encoded by the mutB gene is 91% homologous to that encoded by the E. coli mutY gene.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=196169Documentos Relacionados
- Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of micA and mutY.
- Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein.
- Functional Expression of hMYH, a Human Homolog of the Escherichia coli MutY Protein
- Specific A/G-to-C.G mismatch repair in Salmonella typhimurium LT2 requires the mutB gene product.
- Substrate recognition by Escherichia coli MutY using substrate analogs.
