Nucleotide sequences of trpA of Salmonella typhimurium and Escherichia coli: an evolutionary comparison.
AUTOR(ES)
Nichols, B P
RESUMO
The complete nucleotide sequences of trpA of Salmonella typhimurium and Escherichia coli were determined. The nucleotide sequences are 24.8% divergent, compared with amino acid sequence divergence of 14.9%. Over half of the codons of each gene contain synonymous nucleotide changes. The pattern of synonymous nucleotide changes is consistent with the interpretation that such changes result from random mutational events. We do not find any evidence indicating that codon selection or RNA structure is of major selective value. We conclude that polypeptide function is the primary basis of selection in trpA and that most synonymous codon changes are selectively neutral.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=413117Documentos Relacionados
- Comparison of the nucleoside sequence of trpA and sequences immediately beyond the trp operon of Klebsiella aerogenes. Salmonella typhimurium and Escherichia coli.
- Comparison of dnaA nucleotide sequences of Escherichia coli, Salmonella typhimurium, and Serratia marcescens.
- Translational coupling of the trpB and trpA genes in the Escherichia coli tryptophan operon.
- “Self-Feeding” Strain of Salmonella typhimurium with a Mutation in the trpB Gene and Nutritional Requirements of trpA Gene Mutants1
- Mitomycin C-induced expression of trpA of Salmonella typhimurium inserted into the plasmid ColE1.