Null Mutation of the dam or seqA Gene Suppresses Temperature-Sensitive Lethality but Not Hypersensitivity to Novobiocin of muk Null Mutants
AUTOR(ES)
Onogi, Toshinari
FONTE
American Society for Microbiology
RESUMO
Escherichia coli mukF, mukE, and mukB null mutants have common phenotypes such as temperature-dependent colony formation, anucleate cell production, chromosome cutting by septum closure, and abnormal localization of SeqA-DNA clusters. We show here that the associated muk null mutations cause hypersensitivity to novobiocin. Null mutation of either dam or seqA suppressed partially the temperature-sensitive lethality but failed to suppress the anucleate cell production and the hypersensitivity to novobiocin caused by muk null mutations.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=94715Documentos Relacionados
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