Occurrence of the regulatory nucleotides ppGpp and pppGpp following induction of the stringent response in staphylococci.
AUTOR(ES)
Cassels, R
RESUMO
The stringent response in Escherichia coli and many other organisms is regulated by the nucleotides ppGpp and pppGpp. We show here for the first time that at least six staphylococcal species also synthesize ppGpp and pppGpp upon induction of the stringent response by mupirocin. Spots corresponding to ppGpp and pppGpp on thin-layer chromatograms suggest that pppGpp is the principal regulatory nucleotide synthesized by staphylococci in response to mupirocin, rather than ppGpp as in E. coli.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=177300Documentos Relacionados
- Percent Charging of Transfer Ribonucleic Acid and Levels of ppGpp and pppGpp in Dormant and Germinated Spores of Bacillus megaterium
- Relationship of the first step in protein synthesis to ppGpp: formation of A(5')ppp(5')Gpp.
- The search for guanosine tetraphosphate (ppGpp) and other unusual nucleotides in eucaryotes.
- DksA Affects ppGpp Induction of RpoS at a Translational Level
- Stringency in the absence of ppGpp accumulation in Rhodobacter sphaeroides.
