On the acidity and reactivity of HNO in aqueous solution and biological systems
AUTOR(ES)
Bartberger, Michael D.
FONTE
The National Academy of Sciences
RESUMO
The gas phase and aqueous thermochemistry and reactivity of nitroxyl (nitrosyl hydride, HNO) were elucidated with multiconfigurational self-consistent field and hybrid density functional theory calculations and continuum solvation methods. The pKa of HNO is predicted to be 7.2 ± 1.0, considerably different from the value of 4.7 reported from pulse radiolysis experiments. The ground-state triplet nature of NO− affects the rates of acid-base chemistry of the HNO/NO− couple. HNO is highly reactive toward dimerization and addition of soft nucleophiles but is predicted to undergo negligible hydration (Keq = 6.9 × 10−5). HNO is predicted to exist as a discrete species in solution and is a viable participant in the chemical biology of nitric oxide and derivatives.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=30114Documentos Relacionados
- Adsorption of benzo(a)pyrene on to asbestos and manmade mineral fibres in an aqueous solution and in a biological model solution.
- The Stability of Penicillin in Aqueous Solution
- Impact of HNO3 Solution Treatment of South Brazil Coal Matrices on Their Chemical Composition and Humic Acids Yield
- ON THE ENERGY TRANSFER IN BIOLOGICAL SYSTEMS*
- On the Energy Transfer in Biological Systems