On the Mechanism of Action of Vitamin B12. Model Studies. Thermal Rearrangement of Methyl 3,3-Dimethylglycidate to Methyl Levulinate
AUTOR(ES)
Dowd, Paul
RESUMO
The discovery that methyl 3,3-dimethylglycidate rearranges to methyl levulinate on heating is discussed in terms of its possible consequences for the mechanism of action of the coenzyme B12-dependent enzymes: methylmalonyl-CoA mutase (EC 5.4.99.2), glutamate mutase (EC 5.4.99.1), and a-methyleneglutarate mutase. It is also suggested that the proposed mechanism may provide a unifying link between the mechanism of action of the above enzymes and that of the coenzyme B12-dependent dioldehydrase and related enzymes.
