On the Possibility That DNA Repair Is Related to Age in Non-Dividing Cells
AUTOR(ES)
Wheeler, K. T.
RESUMO
Possible age-related deterioration in the efficacy of DNA repair was investigated in a complement of non-dividing mammalian cells which is not replenished during the lifetime of the animal. Internal granular-layer neurons were extracted from the cerebella of beagle dogs, aged from 7 weeks to 13 years, following exposure in situ to 4700 rads of collimated 60Co gamma rays. The alkaline sucrose-gradient sedimentation profiles obtained from the DNA of those neurons after various post-irradiation periods in situ can be interpreted: (a) that there is not an age-associated decrease in the ability of the cells to rejoin the single-strand breaks induced by radiation, but (b) that there may be an age-associated decline in the size of the DNA-containing species which can be extracted from unirradiated cells. The latter effect may reflect normal aging of the cerebellum.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=388342Documentos Relacionados
- Spontaneous Mutation in Non-Dividing Bacteria
- RNAi-mediated depletion of the 15 KH domain protein, vigilin, induces death of dividing and non-dividing human cells but does not initially inhibit protein synthesis
- Catalase Is Differentially Expressed in Dividing and Nondividing Protoplasts.
- DNA repair in higher plants; photoreactivation is the major DNA repair pathway in non-proliferating cells while excision repair (nucleotide excision repair and base excision repair) is active in proliferating cells
- PATHWAYS OF GLUCOSE OXIDATION IN DIVIDING AND NONDIVIDING CELLS OF ESCHERICHIA COLI1